Proniosome as a Novel Drug Carrier

Proniosome as a Novel Drug Carrier

Description

Carvedilol has oral bioavailability 25% to 30% due to high first pass metabolism (80%) and presence of food decreases its absorption rate in gastrointestinal tract. Short half life of Carvedilol (4 to 6 hr) indicates need of controlled release delivery. To overcome these limitations carvedilol was incorporated in proniosome for transdermal delivery. Proniosome drug delivery was preferred due to improved stability of the system than niosomes. To optimize the formulation, various proniosome gels composed of various ratios of sorbitan fatty acid esters, polysorbates, cholesterol, lecithin were prepared by coacervation-phase separation method. Optimized formulation gave flux 3.416 g/cm2/hr up to 12 hrs. with highest permeation (65%) of carvedilol among all formulations. Penetration enhancers, non-ionic surfactants and vesicle-skin interaction may contributed to the enhanced carvedilol permeation. Thus Proniosome was found to be a promising carrier system for Carvedilol because of ease in preparation and stability for prolonged period.

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Details

Author(s)
Hemant Patil
Format
Paperback | 80 pages
Dimensions
152 x 229 x 5mm | 127g
Publication date
01 Jul 2012
Publisher
LAP Lambert Academic Publishing
Publication City/Country
Saarbrucken, Germany
Language
English
Edition Statement
Aufl.
Illustrations note
black & white illustrations
ISBN10
3659138444
ISBN13
9783659138447